A modified ERG technique and the results obtained in X-linked retinitis pigmentosa.
نویسندگان
چکیده
An electroretinographic (ERG) technique is described in which the relationship between scotopic b wave amplitude and stimulus light intensity is determined. The relative amplitude of scotopic to photopic responses is assessed by means of red light and flicker. The method is applied to the detection of ERG abnormalities in heterozygotes for X-linked retinitis pigmentosa. These have been found in only a proportion of cases. The ERG results can be used to suggest the nature of the retinal abnormality.
منابع مشابه
Four-year placebo-controlled trial of docosahexaenoic acid in X-linked retinitis pigmentosa (DHAX trial): a randomized clinical trial.
IMPORTANCE X-linked retinitis pigmentosa is a severe inherited retinal degenerative disease with a frequency of 1 in 100,000 persons. Because no cure is available for this orphan disease and treatment options are limited, slowing of disease progression would be a meaningful outcome. OBJECTIVE To determine whether high-dose docosahexaenoic acid (DHA), an ω-3 polyunsaturated fatty acid, slows p...
متن کاملDisease course of patients with X-linked retinitis pigmentosa due to RPGR gene mutations.
PURPOSE To measure the rates of visual acuity, visual field, and ERG loss in patients with X-linked retinitis pigmentosa due to RPGR mutations and to determine whether these rates differ from those of patients with dominant retinitis pigmentosa due to RHO mutations. METHODS Snellen visual acuities, Goldmann visual field areas (V4e white test light), and 30 Hz (cone) full-field ERG amplitudes ...
متن کاملApplication of synchronous detector techniques for electroretinographic studies in patients with retinitis pigmentosa.
A description is given of the application of the Synchronous Detector technique for eleciroretinographic (ERG) measurements (cone function) in patients with retinitis pigmentosa. The results obtained, in terms of average amplitudes and average "delay time," are compared with the results obtained by conventional waveform averaging processes. Time delay measurements with the Synchronous Detector ...
متن کاملشب کوری، هتروکرومیا و یووئیت در یک فرد از سلسله بیماران شب‌کور
The classical clinical triad of retinitis pigmentosa is arteriolar attenuation , retinal bone-spicule pigmentation and waxy disc pallor. A 33 year old female patient is introduced here. She had unilateral posterior subcapsular cataract, heterochromic iris, and uveitis.The patient also suffered night blindness , had a family history of low vision ,and reduced visual acuity in her right e...
متن کاملON-pathway dysfunction and timing properties of the flicker ERG in carriers of X-linked retinitis pigmentosa.
PURPOSE Carriers of X-linked retinitis pigmentosa (XLRP) frequently show prolonged implicit times of the flicker electroretinogram (ERG). This study tested the hypothesis that a preferential response attenuation within the cone depolarizing (ON) bipolar cell (DBC) pathway is a major contributing factor. METHODS Light-adapted, full-field ERGs were recorded from 10 XLRP carriers and 12 visually...
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ورودعنوان ژورنال:
- The British journal of ophthalmology
دوره 67 7 شماره
صفحات -
تاریخ انتشار 1983